Outlook 2003 and Mac Mail on OSX earlier than 10.6 (Snow Leopard) are no longer supported. Any mail clients on Windows XP are not supported.

Mail Clients

Client

Exchange 2007

Exchange 2010

Exchange 2013

Exchange 2016

Outlook 2007

+

+

+ (w/SP3)

-

Outlook 2010

+

+

+ (w/SP1)

+ (with KB2965295)

Outlook 2011

+

+

+

+

Outlook 2013

+

+

+

+

Outlook 2016

-

+

+

+

Entourage 2004/2008

+

-

-

-

Entourage 2008 EWS

+

+

+

-

Mail (Mac OS X v10.7 Lion)

+

+

-

-

Mail (Mac OS X v10.8 Mountain Lion)

+

+

+

+

Mail (Mac OS X v10.9 Mavericks)

+

+

+

+

Mail (Mac OS X v10.10 Yosemite)

+

+

+

+

Mail (Mac OS X v10.11 El Capitan)

+

+

+

+

Note: other mail clients (i.e. Thunderbird, Windows Live) can be connected to Exchange mailbox only via POP/IMAP protocol. Read Knowledge Base article on How Can I Connect To My Exchange Server Using POP Or IMAP? for more details.

Skype for Business/Lync Clients

Client

Exchange 2007

Exchange 2010

Exchange 2013

Exchange 2016

Office Communicator 2007

+

-

-

-

Communicator 2011 for Mac

+

-

-

-

Lync 2010

-

+

+

+

Lync 2011 for Mac

-

+

+

+

Lync 2013

-

+

+

+

Skype for Business

-

+

+

+

Lync 2010 Mobile

-

+

-

-

Lync 2013 Mobile

-

-

+

+